Douglas A. Lauffenburger, Jennifer Linderman. 4 Physical Aspects of ReceptorLigand Binding and Trafficking Processes. 133. 5 Signal Transduction. 181. 6 ReceptorMediated Cell Behavioral Responses.
matical models for ligand/receptor interactions and trafficking. Homomeric P2X1 receptors open on binding ATP and then transition to an ATP bound closed desensitized state that requires an agonist free washout period to recover. Crystallographic Methods and Protocols. Voltage clamp fluorometry (VCF) was used to simultaneously record ion channel. activity and conformational changes at defined positions in the extracellular loop of the human P2X1 receptor during not only agonist binding and desensitization, but also recovery.
Lauffenburger's work would be counted among these shining lights when these methods and tools bear fruit sooner than later. Lauffenburger has already provided a glimpse of success of this approach when he worked with Amgen to produce a much pharmacokinetically improved biologic using physiologically based pharmacokinetic model coupled with cellular modeling of receptor-ligand trafficking and binding model)Nature,5 August. Lauffenburger and Linderman are geniuses seeking support for "return to science" for biology. 5 people found this helpful.
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Описание: G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field
Описание: G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. Lauffenburger. PRODUCT DETAILS: Paperback: 376 pages. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis.
Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology. What is Kobo Super Points? A loyalty program that rewards you for your love of reading. Explore rewards Explore Kobo VIP Membership.
Receptors: models for binding, trafficking, and signaling. DA Lauffenburger, JJ Linderman. Physicochemical modelling of cell signalling pathways. BB Aldridge, JM Burke, DA Lauffenburger, PK Sorger. Nature cell biology 8 (11), 1195, 2006. Oxford University Press on Demand, 1996. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Mathematical model for the effects of adhesion and mechanics on cell migration speed. PA DiMilla, K Barbee, DA Lauffenburger.