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eBook Receptors: Models for Binding, Trafficking, and Signaling ePub

by Jennifer Linderman,Douglas A. Lauffenburger

eBook Receptors: Models for Binding, Trafficking, and Signaling ePub
Author: Jennifer Linderman,Douglas A. Lauffenburger
Language: English
ISBN: 0195064666
ISBN13: 978-0195064667
Publisher: Oxford University Press; First Edition edition (August 5, 1993)
Pages: 376
Category: Biological Sciences
Subcategory: Science
Rating: 4.5
Votes: 785
Formats: mobi txt rtf lit
ePub file: 1634 kb
Fb2 file: 1810 kb

Douglas A. Lauffenburger, Jennifer Linderman. 4 Physical Aspects of ReceptorLigand Binding and Trafficking Processes. 133. 5 Signal Transduction. 181. 6 ReceptorMediated Cell Behavioral Responses.

Douglas A.

matical models for ligand/receptor interactions and trafficking. Homomeric P2X1 receptors open on binding ATP and then transition to an ATP bound closed desensitized state that requires an agonist free washout period to recover. Crystallographic Methods and Protocols. Voltage clamp fluorometry (VCF) was used to simultaneously record ion channel. activity and conformational changes at defined positions in the extracellular loop of the human P2X1 receptor during not only agonist binding and desensitization, but also recovery.

Lauffenburger's work would be counted among these shining lights when these methods and tools bear fruit sooner than later. Lauffenburger has already provided a glimpse of success of this approach when he worked with Amgen to produce a much pharmacokinetically improved biologic using physiologically based pharmacokinetic model coupled with cellular modeling of receptor-ligand trafficking and binding model)Nature,5 August. Lauffenburger and Linderman are geniuses seeking support for "return to science" for biology. 5 people found this helpful.

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Описание: G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field

Описание: G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. Lauffenburger. PRODUCT DETAILS: Paperback: 376 pages. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis.

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology. What is Kobo Super Points? A loyalty program that rewards you for your love of reading. Explore rewards Explore Kobo VIP Membership.

Receptors: models for binding, trafficking, and signaling. DA Lauffenburger, JJ Linderman. Physicochemical modelling of cell signalling pathways. BB Aldridge, JM Burke, DA Lauffenburger, PK Sorger. Nature cell biology 8 (11), 1195, 2006. Oxford University Press on Demand, 1996. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Mathematical model for the effects of adhesion and mechanics on cell migration speed. PA DiMilla, K Barbee, DA Lauffenburger.

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.
Saimath
Paid a ton of money to overnight this thing, have only ever read one page of it, and in fact I don't even really know what it's about, but it's perhaps the most important $86.37 that I've ever invested in my future. Thank you Dr. Lauffenburger.
Duzshura
This book will surely be thought of as the first structured presentation of principles of modern systems biology. This book introduces the application of Chemical Engineering to biologists and molecular biology and pharmacology of receptors to Chemical Engineers. The top-down picture of coupled processes is not only new to biologists but introduces a whole new way to look at biological problems. Especially the chapter which has cell migration explained introduces one to multi-dimensional thinking: cell mechanics, biochemistry, kinetic modeling and molecular biology all in the same problem. This may seem mystical to many. Would probably be read more by Engineers than biologists, who are yet to take the leap in thought to multi-dimensional science.This book would be remembered after many years to be a pioneer in the new science of systems biology, although it was written much before the Human Genome Project. Systems thinking and Chemical Engineering has been much beneficial in solving some very important biomedical problems like Drug Delivery(Robert Langer), Tumor Biology(Rakesh Jain) and Tissue Engineering(Robert Langer et.al.). Lauffenburger's work would be counted among these shining lights when these methods and tools bear fruit sooner than later.(Lauffenburger has already provided a glimpse of success of this approach when he worked with Amgen to produce a much pharmacokinetically improved biologic using physiologically based pharmacokinetic model coupled with cellular modeling of receptor-ligand trafficking and binding model)Nature,5 August 2002.Lauffenburger and Linderman are geniuses seeking support for "return to science" for biology.
Nawenadet
This book will surely be thought of as the first structured presentation of principles of modern systems biology. This book introduces the application of Chemical Engineering to biologists and molecular biology and pharmacology of receptors to Chemical Engineers. The top-down picture of coupled processes is not only new to biologists but introduces a whole new way to look at biological problems. Especially the chapter which has cell migration explained introduces one to multi-dimensional thinking: cell mechanics, biochemistry, kinetic modeling and molecular biology all in the same problem. This may seem mystical to many. Would probably be read more by Engineers than biologists, who are yet to take the leap in thought to multi-dimensional science.This book would be remembered after many years to be a pioneer in the new science of systems biology, although it was written much before the Human Genome Project. Systems thinking and Chemical Engineering has been much beneficial in solving some very important biomedical problems like Drug Delivery(Robert Langer), Tumor Biology(Rakesh Jain) and Tissue Engineering(Robert Langer et.al.). Lauffenburger's work would be counted among these shining lights when these methods and tools bear fruit sooner than later.(Lauffenburger has already provided a glimpse of success of this approach when he worked with Amgen to produce a much pharmacokinetically improved biologic using physiologically based pharmacokinetic model coupled with cellular modeling of receptor-ligand trafficking and binding model)Nature,5 August 2002.Lauffenburger and Linderman are geniuses seeking support for "return to science" for biology.
Hamrl
If you are thinking of purchasing a book on receptor-ligand kinetics, this is a wise choice. It is easy to follow and advanced enough for most graduate work in biochemical and biomedical engineering.
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